Биологи открыли ранее неизвестный механизм действия антител на вирусы: Благодаря этому можно будет создавать новые лекарства на основе моноклональных антител, надеются ученые

2021.11.30 18:32 postmastern Биологи открыли ранее неизвестный механизм действия антител на вирусы: Благодаря этому можно будет создавать новые лекарства на основе моноклональных антител, надеются ученые

Биологи открыли ранее неизвестный механизм действия антител на вирусы: Благодаря этому можно будет создавать новые лекарства на основе моноклональных антител, надеются ученые Ученые выяснгили, что некоторые антитела могут деформировать структуру оболочек вирусов, чтобы те не могли присоединиться к поверхности заражаемых клеток. Результаты исследования опубликовал научный журнал Cell01324-6).
© Kevin FrayeGetty Images
"Считается, что антитела соединяются с вирусами и блокируют работу их белков, которые нужны для заражения клетки. Мы выяснили, что некоторые антитела могут столь сильно деформировать вирусные частицы, что те просто не могут прикрепиться к заражаемым клеткам", – сказал один из авторов исследования, доцент Пенсильванского университета Ганеш Ананд.
Антитела – это крупные белковые молекулы, которые состоят из нескольких длинных цепочек аминокислот. Они соединены друг с другом таким образом, что эти белковые нити могут соединяться только с определенно устроенными молекулами, которые присутствуют на поверхности вирусов, бактерий или других опасных объектов микромира.
В случае с микробами и грибками антитела служат "метками", которые привлекают внимание клеток иммунной системы и заставляют их уничтожить помеченный объект. Если же антитело присоединяется к вирусу, то оно, как считали ученые до недавнего времени, не дает белкам оболочки патогена соединиться со здоровой клеткой и ввести в нее генетический материал вируса.
Ананд и его коллеги обнаружили, что существует как минимум еще один тип антител с совершенно иным механизмом действия на вирусные частицы. Ученые совершили это открытие во время опытов с моноклональными антителами, которые могут нейтрализовать частицы вирусов Зика и лихорадки денге.
Необычно широкий спектр действия этих молекул, получивших имя C10, заинтересовал биологов и заставил их детально проследить за тем, как эти антитела соединялись с частицами и того, и другого вируса. Для этого ученые соединили вирусные частицы и молекулы C10, заморозили их и просветили при помощи криоэлектронного микроскопа.
Эти снимки и спектроскопические наблюдения неожиданно указали на то, что молекулы C10 по-разному взаимодействовали с частицами вирусов Зика и денге. В первом случае они блокировали реакции между вирусными белками и оболочкой клеток, тогда как при соединении с частицами вируса денге антитела столь сильно деформировали их оболочку, что те теряли способность сцепляться с поверхностью клеток.
Подобная особенность этих антител не только объясняет, почему молекулы С10 могут нейтрализовать два разных патогена, но и указывает на существование ранее неизвестного механизма действия антител на вирусы. Эту особенность антител можно использовать для создания новых моноклональных препаратов, способных одинаково эффективно нейтрализовать сразу несколько видов вирусов, подытожили ученые.
Источник: НаукаТАСС
submitted by postmastern to Popular_Science_Ru [link] [comments]


2021.11.30 18:32 _dirtywords Tree planted in my mom’s yard - NC mountains

My mom thought this tree was a magnolia, planted by the previous home owner, but I’m pretty sure it’s not - unless there’s a magnolia with serrated/teeth edges. So, the rest of the trees in her yard have lost their leaves for the winter - this one is clearly not going to. She moved in about a year ago and she can’t remember if it flowered last spring/summer or not, but it does have some small red berries now. The leaves are shiny, large-ish (slightly larger than my palm?), and have serrated edges. Any ideas?
Also, I tried ID-ing it with an app and got several different answers: Carolina Cherry Laurel (maybe?), Sakaki (Cleyera japonica) - also doesn’t seem right, and Chinese photo is. Any help would be great!
submitted by _dirtywords to whatsthisplant [link] [comments]


2021.11.30 18:32 OfficialPYTseller Cheap PYT packs. 200+ for 5$‼️. Hml✅dm🔌

Cheap PYT packs. 200+ for 5$‼️. Hml✅dm🔌 submitted by OfficialPYTseller to goshhd [link] [comments]


2021.11.30 18:32 wariatspierdolony 5000 Mobox Mystery Box Giveaway on Binance (Random)

WHOPPING 5000 Mystery BOX Giveaway worth $1,000,000 BUSD distributed randomly.
Guide:

  1. Signup or login on binance ref link
  2. Download the latest mobile app from playstore or appstore
  3. Once you open the Binance App simply drag down from the homepage to access the “ Marketplace”
  4. You will see the MOBOX logo 'Mobox games'
  5. Generate nft avatar
  6. Then you will see $1,000,000 NFT Giveaway header
  7. Press join now and enter referral avatar id
  8. You can share your avatar id in comments below
My avatar id Avatar #5029267
submitted by wariatspierdolony to CryptoShareApp [link] [comments]


2021.11.30 18:32 treatking Bid to win Billy Joel Tickets and a SIGNED vinyl collection!!!

Fight hunger and bid to win 2 tickets to see Billy Joel at MSG in NYC plus a SIGNED vinyl collection! Bid Now to support WhyHunger: https://www.charitybuzz.com/catalog_items/auction-2-tickets-to-see-billy-joel-at-msg-in-nyc-plus-2304169
submitted by treatking to BillyJoel [link] [comments]


2021.11.30 18:32 RidgebackDaddy Can you use racing sim pedals as pedals for flight simulator?

submitted by RidgebackDaddy to LogitechG [link] [comments]


2021.11.30 18:32 Louis_iverson Tomorrows play?

submitted by Louis_iverson to Shortsqueeze [link] [comments]


2021.11.30 18:32 Global-KingHeylel999 A’mein (9) ⁦‪@Shibtoken‬⁩ over $12,323,344.73 in #SHIB purchase

A’mein (9) ⁦‪@Shibtoken‬⁩ over $12,323,344.73 in #SHIB purchase submitted by Global-KingHeylel999 to shibainucoinburn [link] [comments]


2021.11.30 18:32 PrusRuslan [ For Sale ]My oil painting. Mediterranean landscape. Oil on canvas. 2021. Available on Etsy.

[ For Sale ]My oil painting. Mediterranean landscape. Oil on canvas. 2021. Available on Etsy. submitted by PrusRuslan to artstore [link] [comments]


2021.11.30 18:32 Blayrr Any way to fix elite series 2?

I dropped my elite series 2 because I’m the dumbest human alive and now it won’t connect to my pc. I’ve used multiple different cables so I’m pretty confident it’s a controller issue. Is there any way I can fix this myself? My warranty expired so can’t replace it. All help is appreciated
submitted by Blayrr to xbox [link] [comments]


2021.11.30 18:32 ceps2111 The Undertaker's Mt. Rushmore of WWE: Andre The Giant, Stone Cold Steve Austin, The Rock and Shawn Michaels

submitted by ceps2111 to SquaredCircle [link] [comments]


2021.11.30 18:32 Present-Call-3781 LabradorCoin Token ($LBDC) is a community-focused, decentralized cryptocurrency with a special self-driven cell-division mechanism.

LabradorCoin Token ($LBDC) is a community-focused, decentralized cryptocurrency with a special self-driven cell-division mechanism. LabradorCoin Token ($LBDC) is a community-focused, decentralized cryptocurrency with a special self-driven cell-division mechanism.
https://preview.redd.it/qh2jx3f2xs281.jpg?width=706&format=pjpg&auto=webp&s=2f8be88d5703d129ec19103193e5862bfc0d26b1
While holders are rewarded with reflections from each transaction we also automatically reward community members that help to build the coin.

The first BSC token of its kind. Every $LBDC holder can invite people to join the coin.
When you send a small amount of $LBDC to someone, you are their inviter and will be rewarded as they join and invest in the token.
This directly rewards the community members that actively help us grow $LBDC !

This is an international project with a core Chinese development team working alongside
a UK based crypto team that are helping to build the English-language community, marketing,
and competitions. We truly believe this coin could be the next big thing. We are unique,
focused on rewarding our active community, have international reach, and most importantly  .
Seriously tho – we have huge plans for this coin. We are currently promoting with adverts live on PooCoin and …..!

This coin is perfect for TwitteReddit competitions – so if you like Airdrops this coin is going to go crazy in the near future!

TOKENOMICS: A 10% Tax is charged on each transaction: 4% added to LOCKED LP 2% reflections of each transaction go to holders

Now let's get . $LBDC holders are rewarded automatically when they help to bring others to join.
By sharing just 10k $LBDC to addresses which have not been invited yet, you will be their inviter.
As thanks for bringing them to our community you'll be rewarded 2.4% distributed to inviter 1.6% distributed
to inviter's inviter Instant rewards building LabradorCoin


LINKS :

💬 Telegram: https://t.me/LabradorCoinBsc





🥞 PancakeSwap (V2):
https://exchange.pancakeswap.finance/#/swap?outputCurrency=0x0Ae49d78e0f50060e24B809E1035E74140618135


📈 Chart (Bogged): https://charts.bogged.finance/?token=0x0Ae49d78e0f50060e24B809E1035E74140618135
submitted by Present-Call-3781 to PooCoin [link] [comments]


2021.11.30 18:32 ZiraelN7 Oops, my bad...

Oops, my bad... submitted by ZiraelN7 to WatchPeopleDieInside [link] [comments]


2021.11.30 18:32 StarFox64HappenedIRL Do people play Little Cup (LC) on BDSP?

I was looking to get into LC in game, but was wondering if there was any set group or discord that does it on BDSP.
submitted by StarFox64HappenedIRL to PokemonBDSP [link] [comments]


2021.11.30 18:32 tc182 Kristin Kreuk

Kristin Kreuk submitted by tc182 to 1998TeenMovie [link] [comments]


2021.11.30 18:32 Karl-Fowler77 SekiroShadowDieTwice

submitted by Karl-Fowler77 to SekiroShadowDieTwice [link] [comments]


2021.11.30 18:32 neonthewolf I got a PCR day 2 test for £1 through the Gov.U.K. site, what’s the chance I’m being scammed?

It’s an on site test in Battersea, it was listed for £1. I took it, I’m unsure what happens now! I got my booking code, it seems to check out…
If it’s legit, I think I’ll get a few more for future travel…
submitted by neonthewolf to uktravel [link] [comments]


2021.11.30 18:32 SpartanR259 Things that defined Halo for me and why right now Infinite feels like a Betrayal

So amidst all the issues going around Halo Infinite right now, I thought I would share some of the things that have disappeared from this franchise with this game (as it stands right now.)

  1. Social fun. Halo always had a place for me to escape and have fun. Hop on an open mic and joke and jeer at each other as you would trade compliments and insults. But open mic is a removed feature to "limit toxicity" in the game. this is interesting to me because these games have always had this wonderful feature called: mute. if someone was an absolute tool you could just cut them out of the conversation. This change doesn't "limit toxicity" it panders to the fragile. And it is why it should have stayed rated M.
  2. Shenanigans. Gone now are the days of mocking up some ridiculous emblem and color scheme and just rolling into a game and playing like idiots. Some of my favorite memories are of playing halo 3 and reach making a 4 stack with friends and coloring ourselves hot pink (I mean lightish red) and giving ourselves stupid parameters. Pistols only, carbines only, fists, and just being silly in general. Over a night of games, we would make some random friends and plan again for the next time. But this is gone now because the colors are locked up; as are the emblems. And don't even get started on the "challenges."
  3. Finally, Halo was played because it was Halo and for no other reason. If you wanted to play a shooter; there were other "better" games. You played halo because of the way this game was played. it is not a fast-paced game. (though at times depending on the game type it can be) It took a level of commitment to get kills. You couldn't run and gun with the sniper because other guns could outplay you at closer range. You had to work as a team to win games, and that built the community up. K/D was an afterthought most of the time because the objective was fun. If you weren't having fun you stopped playing. And Infinite has gotten so much right with the actual gameplay. But this is gone now too because players are forced into games they don't want to play. So investment drops.
It really hurts my heart to see the game (franchise) I love, take such a drastic misstep. The fun is gone and all that remains is a grind that no one asked for. You won't make friends because everyone is too busy completing their challenges or quitting games that they didn't want to play. In the nearly 20 hours of playtime, I have in this game all I have to show for it is some lost memories and a great deal of frustration.
I still look forward to the campaign but it looks like MP might just be a "miss" for me.
submitted by SpartanR259 to halo [link] [comments]


2021.11.30 18:32 alisonroman TUNAT now accepts Bitcoin and ETH

DM me for this amazing opportunity
submitted by alisonroman to LVSSSupport [link] [comments]


2021.11.30 18:32 BagsRVA The December 2021 issue of Men’s Health is out now! Behold:

submitted by BagsRVA to jrvp [link] [comments]


2021.11.30 18:32 Dandyboi Weird artifacts on flat print through layers

submitted by Dandyboi to FixMyPrint [link] [comments]


2021.11.30 18:32 Joemoms4839 Dynamics problem

Our teacher missed three days straight, meaning he just posted the notes and said do the questions. The supplies were clueless and no help. I don’t have a good understanding on tension, the topic he said to teach ourselves today. I don’t get this question. I know a bit of the tension concept but can’t seem to fully grasp it. Question: an old rope can now only safely suspend 120 kg when the rope is tied to a beam. it hangs down with a vertical length of 12.0 m. calculate the minimum time required for an 85 kg person starting from rest to climb the entire length of the rope without breaking it.
submitted by Joemoms4839 to AskPhysics [link] [comments]


2021.11.30 18:32 Maverick9922 Question about push/pull water cooler configuration

Hi guys, this is like my second ever PC build and I'm not sure if I did it correctly. As you can see, fans are on top and radiator is right below, attached to the fans. Is this configuration pushing hot air out of the case or pulling cold air into the case?
Here is a picture: https://i.imgur.com/d4yCfVy.jpeg
submitted by Maverick9922 to buildapc [link] [comments]


2021.11.30 18:32 HoboPhD Pandemic statistics for the D.C. + NoVA + MoCo + PG's County agglomeration, 2021-11-30 [OC]

submitted by HoboPhD to nova [link] [comments]


2021.11.30 18:32 prabijeynxdxd SUGGESTIONS

I'm planning to buy Acer AN515-57-5620 before Christmas. Any reviews or suggestions about it? I've read so many thermal issues from the previous models and now I'm doubting my choices.
submitted by prabijeynxdxd to AcerNitro [link] [comments]


http://relefrossii.ru